Macrocyclic Glycoclusters: From Amphiphiles through Nanoparticles to Glycoviruses
Identifieur interne : 003139 ( Main/Exploration ); précédent : 003138; suivant : 003140Macrocyclic Glycoclusters: From Amphiphiles through Nanoparticles to Glycoviruses
Auteurs : Yasuhiro Aoyama [Japon]Source :
- Chemistry – A European Journal [ 0947-6539 ] ; 2004-02-06.
English descriptors
- Teeft :
- Aggregation, Aoyama, Aoyama concepts, Artificial viruses, Cell surface, Chem, Common aspect, Complexation, Definite number, Gene delivery, Glycocluster, Glycocluster amphiphiles, Glycocluster nanoparticles, Glycocluster part, Glycoclusters, Glycoviruses, Hela cells, Hepatic cells, Hierarchical adhesion control, Hierarchical growth, Hydrophobicity, Important roles, Macrocyclic, Macrocyclic glycocluster amphiphiles, Macrocyclic glycoclusters, Nanoparticles, Other hand, Other words, Saccharide, Same time, Similar manner, Size factor, Transfection efficiencies, Transmission electron microscopy, Unusual stability, Verlag gmbh, Weinheim chem.
Abstract
Macrocyclic glycocluster amphiphiles are intended to be a covalent‐bundle mimic of clustering glycolipid motifs on the cell membrane. They are irreversibly micellized to give glycocluster nanoparticles (GNPs); their masked hydrophobicity endows them with remarkable saccharide specificities in the interactions with biological saccharide receptors. The GNPs also exhibit unprecedented hydrogen‐bond capacities; they are agglutinated with Na2HPO4 and assembled on plasmid DNA in a number‐, size‐, and shape‐controlled manner to give artificial glycoviral particles capable of transfection. Thus, the intrinsic function of viruses, that is, cell invasion followed by gene expression, is also intrinsic to size‐regulated (∼50 nm) glycoviruses. The growth of glycocluster amphiphiles through nanoparticles to glycoviruses reveals a hierarchical adhesion control of the saccharide clusters.
Masked hydrophobicity is observed in micellar glycocluster nanoparticles (GNPs) which are formed irreversibly in water by macrocyclic glycocluster amphiphiles. The GNPs are remarkably sticky on the phosphate groups of DNA, giving rise to number‐, size‐, and shape‐controlled glycoviral particles capable of transfection.
Url:
DOI: 10.1002/chem.200305288
Affiliations:
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They are irreversibly micellized to give glycocluster nanoparticles (GNPs); their masked hydrophobicity endows them with remarkable saccharide specificities in the interactions with biological saccharide receptors. The GNPs also exhibit unprecedented hydrogen‐bond capacities; they are agglutinated with Na2HPO4 and assembled on plasmid DNA in a number‐, size‐, and shape‐controlled manner to give artificial glycoviral particles capable of transfection. Thus, the intrinsic function of viruses, that is, cell invasion followed by gene expression, is also intrinsic to size‐regulated (∼50 nm) glycoviruses. The growth of glycocluster amphiphiles through nanoparticles to glycoviruses reveals a hierarchical adhesion control of the saccharide clusters.</div><div type="abstract" xml:lang="en">Masked hydrophobicity is observed in micellar glycocluster nanoparticles (GNPs) which are formed irreversibly in water by macrocyclic glycocluster amphiphiles. The GNPs are remarkably sticky on the phosphate groups of DNA, giving rise to number‐, size‐, and shape‐controlled glycoviral particles capable of transfection.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région du Kansai</li></region><settlement><li>Kyoto</li></settlement><orgName><li>Université de Kyoto</li></orgName></list><tree><country name="Japon"><region name="Région du Kansai"><name sortKey="Aoyama, Yasuhiro" sort="Aoyama, Yasuhiro" uniqKey="Aoyama Y" first="Yasuhiro" last="Aoyama">Yasuhiro Aoyama</name></region><name sortKey="Aoyama, Yasuhiro" sort="Aoyama, Yasuhiro" uniqKey="Aoyama Y" first="Yasuhiro" last="Aoyama">Yasuhiro Aoyama</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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